Hyperglycaemia after Moxidectin (ProHeart 6) in dogs

208 reports to the FDA describe hyperglycaemia in dogs given Moxidectin. That is 0.4% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

208Reports

63%Marked serious

11%Recovered

27%Died or euthanised

1 daysTypical onset

How soon it started

Same day

56 42%

1–2 days

23 17%

3–7 days

17 13%

1–4 weeks

18 13%

Over a month

20 15%

How the animals did

Recovered

23 11%

Still unwell when reported

89 43%

Died

35 17%

Euthanised

21 10%

Not known

40 19%

Problems reported at the same time

123 59%

104 50%

95 46%

72 35%

72 35%

58 28%

55 26%

47 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause hyperglycaemia in dogs?: 208 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperglycaemia with similar medicines

Hyperglycaemia after Ivermectin + Pyrantel (Heartgard Plus) 225 reports · 0.2% of its reports
Hyperglycaemia after Milbemycin Oxime + Spinosad (Trifexis) 356 reports · 0.3% of its reports
Hyperglycaemia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 77 reports · 0.2% of its reports
Hyperglycaemia after Milbemycin Oxime (Interceptor) 51 reports · 0.2% of its reports
Hyperglycaemia after Selamectin (Revolution) 58 reports · 0.2% of its reports
Hyperglycaemia after Ivermectin (Heartgard) 77 reports · 0.6% of its reports
Hyperglycaemia after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 23 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with hyperglycaemia