Injection site reaction after Midazolam in dogs

The FDA has received 86 reports of injection site reaction in dogs after Midazolam. That is 7.1% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

86Reports

48%Marked serious

30%Recovered

3.5%Died or euthanised

3 daysTypical onset

How soon it started

Same day

23 30%

1–2 days

15 19%

3–7 days

20 26%

1–4 weeks

12 16%

Over a month

7 9.1%

How the animals did

Recovered

25 29%

Recovered with lasting effects

1 1.2%

Still unwell when reported

25 29%

Died

1 1.2%

Euthanised

2 2.3%

Not known

32 37%

Problems reported at the same time

Swelling

48 56%

Loss of appetite

22 26%

Lethargy

19 22%

Didn't work as expected

17 20%

Lameness

13 15%

Pain

12 14%

Wound

12 14%

Diarrhea

11 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Midazolam cause injection site reaction in dogs?: 86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Melarsomine (Immiticide) 3,290 reports · 15% of its reports
Injection site reaction after Polysulfated Glycosaminoglycan 263 reports · 4.8% of its reports
Injection site reaction after Diphenhydramine 398 reports · 8.4% of its reports
Injection site reaction after Butorphanol 479 reports · 11% of its reports
Injection site reaction after Cefpodoxime 81 reports · 2.0% of its reports
Injection site reaction after Tramadol 123 reports · 3.3% of its reports
Injection site reaction after Desoxycorticosterone Pivalate 165 reports · 4.9% of its reports
Injection site reaction after Propofol 170 reports · 5.5% of its reports
Injection site reaction after Isoflurane 126 reports · 4.6% of its reports
Injection site reaction after Cephalexin 31 reports · 1.2% of its reports

All reported side effects of Midazolam in dogs · Medicines most reported with injection site reaction