Application site reaction after Miconazole + Polymyxin B + Prednisolone in dogs

24 reports to the FDA describe application site reaction in dogs given Miconazole + Polymyxin B + Prednisolone. That is 2.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports
13%Marked serious
17%Recovered
0.0%Died or euthanised
5 daysTypical onset
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How soon it started

Same day
4 29%
1–2 days
0 0.0%
3–7 days
4 29%
1–4 weeks
3 21%
Over a month
3 21%

How the animals did

Recovered
4 17%
Still unwell when reported
6 25%
Not known
14 58%

Problems reported at the same time

4 17%
Skin rash or irritation
3 13%

Age of the animals

Under 1 year
1
1–3 years
3
4–7 years
10
8–11 years
7
12+ years
2

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Miconazole + Polymyxin B + Prednisolone cause application site reaction in dogs?
24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 5 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Application site reaction with similar medicines

All reported side effects of Miconazole + Polymyxin B + Prednisolone in dogs · Medicines most reported with application site reaction