Localised pain (see other 'socs' for specific pain) after Melarsomine (Immiticide) in dogs

The FDA has received 72 reports of localised pain (see other 'socs' for specific pain) in dogs after Melarsomine. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

72Reports

54%Marked serious

9.7%Recovered

6.9%Died or euthanised

10 daysTypical onset

How soon it started

Same day

20 31%

1–2 days

6 9.2%

3–7 days

4 6.2%

1–4 weeks

16 25%

Over a month

19 29%

How the animals did

Recovered

7 9.7%

Still unwell when reported

45 63%

Died

3 4.2%

Euthanised

2 2.8%

Not known

15 21%

Problems reported at the same time

Swelling

19 26%

Lethargy

16 22%

Loss of appetite

15 21%

Injection site reaction

14 19%

9 13%

9 13%

9 13%

8 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause localised pain (see other 'socs' for specific pain) in dogs?: 72 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Localised pain (see other 'socs' for specific pain) with similar medicines

Localised pain (see other 'socs' for specific pain) after Diphenhydramine 51 reports · 1.1% of its reports
Localised pain (see other 'socs' for specific pain) after Butorphanol 39 reports · 0.9% of its reports
Localised pain (see other 'socs' for specific pain) after Cefpodoxime 40 reports · 1.0% of its reports
Localised pain (see other 'socs' for specific pain) after Tramadol 49 reports · 1.3% of its reports
Localised pain (see other 'socs' for specific pain) after Propofol 24 reports · 0.8% of its reports
Localised pain (see other 'socs' for specific pain) after Famotidine 35 reports · 1.3% of its reports
Localised pain (see other 'socs' for specific pain) after Tigilanol Tiglate 25 reports · 1.2% of its reports
Localised pain (see other 'socs' for specific pain) after Methocarbamol 20 reports · 3.2% of its reports

All reported side effects of Melarsomine in dogs · Medicines most reported with localised pain (see other 'socs' for specific pain)