Overdose after Lotilaner (Credelio) in dogs

The FDA has received 111 reports of overdose in dogs after Lotilaner. That is 1.1% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

111Reports
19%Marked serious
29%Recovered
3.6%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
50 53%
1–2 days
8 8.5%
3–7 days
5 5.3%
1–4 weeks
9 9.6%
Over a month
22 23%

How the animals did

Recovered
32 29%
Still unwell when reported
34 31%
Died
3 2.7%
Euthanised
1 0.9%
Not known
41 37%

Problems reported at the same time

Age of the animals

Under 1 year
26
1–3 years
36
4–7 years
14
8–11 years
16
12+ years
12

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause overdose in dogs?
111 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

All reported side effects of Lotilaner in dogs · Medicines most reported with overdose