Overdose after Fluralaner (Bravecto) in dogs

The FDA has received 846 reports of overdose in dogs after Fluralaner. That is 1.2% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

846Reports

47%Marked serious

24%Recovered

1.7%Died or euthanised

1 daysTypical onset

How soon it started

Same day

182 49%

1–2 days

41 11%

3–7 days

18 4.9%

1–4 weeks

42 11%

Over a month

87 24%

How the animals did

Recovered

205 24%

Recovered with lasting effects

2 0.2%

Still unwell when reported

563 67%

Died

9 1.1%

Euthanised

5 0.6%

Not known

62 7.3%

Problems reported at the same time

329 39%

212 25%

150 18%

77 9.1%

Didn't work as expected

69 8.2%

Accidental exposure

65 7.7%

Drug administration error

63 7.4%

Diarrhea

56 6.6%

Age of the animals

Under 1 year

108

1–3 years

251

4–7 years

237

8–11 years

152

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause overdose in dogs?: 846 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

Overdose after Afoxolaner (NexGard) 581 reports · 1.0% of its reports
Overdose after Sarolaner (Simparica) 326 reports · 2.0% of its reports
Overdose after Lotilaner (Credelio) 111 reports · 1.1% of its reports
Overdose after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 22 reports · 0.2% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with overdose