Lameness after Lotilaner (Credelio) in dogs

149 reports to the FDA describe lameness in dogs given Lotilaner. That is 1.5% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

149Reports

27%Marked serious

15%Recovered

5.4%Died or euthanised

92 daysTypical onset

How soon it started

Same day

9 8.9%

1–2 days

6 5.9%

3–7 days

7 6.9%

1–4 weeks

12 12%

Over a month

67 66%

How the animals did

Recovered

22 15%

Still unwell when reported

50 34%

Died

4 2.7%

Euthanised

4 2.7%

Not known

69 46%

Problems reported at the same time

Didn't work as expected

56 38%

41 28%

27 18%

22 15%

21 14%

17 11%

13 8.7%

12 8.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause lameness in dogs?: 149 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 92 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lameness with similar medicines

Lameness after Fluralaner (Bravecto) 362 reports · 0.5% of its reports
Lameness after Afoxolaner (NexGard) 337 reports · 0.6% of its reports
Lameness after Sarolaner (Simparica) 88 reports · 0.5% of its reports
Lameness after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 43 reports · 0.5% of its reports
Lameness after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 36 reports · 1.2% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with lameness