Didn't stop ticks after Lotilaner (Credelio) in dogs

The FDA has received 843 reports of didn't stop ticks in dogs after Lotilaner. That is 8.5% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

843Reports

4.2%Marked serious

0.4%Recovered

0.0%Died or euthanised

50 daysTypical onset

How soon it started

Same day

40 7.3%

1–2 days

20 3.7%

3–7 days

37 6.8%

1–4 weeks

138 25%

Over a month

312 57%

How the animals did

Recovered

3 0.4%

Still unwell when reported

53 6.3%

Not known

787 93%

Problems reported at the same time

Didn't work as expected

487 58%

35 4.2%

23 2.7%

22 2.6%

21 2.5%

18 2.1%

17 2.0%

14 1.7%

Age of the animals

Under 1 year

154

1–3 years

343

4–7 years

170

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause didn't stop ticks in dogs?: 843 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 50 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop ticks with similar medicines

Didn't stop ticks after Fluralaner (Bravecto) 6,711 reports · 9.8% of its reports
Didn't stop ticks after Afoxolaner (NexGard) 8,328 reports · 15% of its reports
Didn't stop ticks after Sarolaner (Simparica) 2,073 reports · 12% of its reports
Didn't stop ticks after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 273 reports · 2.9% of its reports
Didn't stop ticks after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 53 reports · 1.7% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with didn't stop ticks