Elevated cholesterol (total) after Lotilaner (Credelio) in dogs
The FDA has received 29 reports of elevated cholesterol (total) in dogs after Lotilaner. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.
29Reports
66%Marked serious
3.4%Recovered
17%Died or euthanised
96 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Lotilaner kills fleas and ticks; monthly chewable.
Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Questions owners ask
- Can Lotilaner cause elevated cholesterol (total) in dogs?
- 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 96 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Elevated cholesterol (total) with similar medicines
- Elevated cholesterol (total) after Fluralaner (Bravecto) 146 reports · 0.2% of its reports
- Elevated cholesterol (total) after Afoxolaner (NexGard) 126 reports · 0.2% of its reports
- Elevated cholesterol (total) after Sarolaner (Simparica) 23 reports · 0.1% of its reports
All reported side effects of Lotilaner in dogs · Medicines most reported with elevated cholesterol (total)