Elevated amylase after Lotilaner (Credelio) in dogs
28 reports to the FDA describe elevated amylase in dogs given Lotilaner. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.
28Reports
68%Marked serious
18%Recovered
21%Died or euthanised
48 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Lotilaner kills fleas and ticks; monthly chewable.
Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Questions owners ask
- Can Lotilaner cause elevated amylase in dogs?
- 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 48 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Elevated amylase with similar medicines
- Elevated amylase after Fluralaner (Bravecto) 174 reports · 0.3% of its reports
- Elevated amylase after Afoxolaner (NexGard) 117 reports · 0.2% of its reports
- Elevated amylase after Sarolaner (Simparica) 26 reports · 0.2% of its reports
- Elevated amylase after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 20 reports · 0.2% of its reports
All reported side effects of Lotilaner in dogs · Medicines most reported with elevated amylase