Disorientation after Lotilaner (Credelio) in dogs

The FDA has received 109 reports of disorientation in dogs after Lotilaner. That is 1.1% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

109Reports

49%Marked serious

40%Recovered

4.6%Died or euthanised

1 daysTypical onset

How soon it started

Same day

32 36%

1–2 days

18 20%

3–7 days

5 5.7%

1–4 weeks

10 11%

Over a month

23 26%

How the animals did

Recovered

44 40%

Still unwell when reported

40 37%

Died

1 0.9%

Euthanised

4 3.7%

Not known

20 18%

Problems reported at the same time

38 35%

34 31%

27 25%

26 24%

24 22%

21 19%

15 14%

15 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause disorientation in dogs?: 109 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Fluralaner (Bravecto) 660 reports · 1.0% of its reports
Disorientation after Afoxolaner (NexGard) 663 reports · 1.2% of its reports
Disorientation after Sarolaner (Simparica) 349 reports · 2.1% of its reports
Disorientation after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 109 reports · 1.2% of its reports
Disorientation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 28 reports · 0.9% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with disorientation