Disorientation after Fluralaner (Bravecto) in dogs

The FDA has received 660 reports of disorientation in dogs after Fluralaner. That is 1.0% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

660Reports

88%Marked serious

34%Recovered

15%Died or euthanised

2 daysTypical onset

How soon it started

Same day

116 31%

1–2 days

93 24%

3–7 days

48 13%

1–4 weeks

41 11%

Over a month

82 22%

How the animals did

Recovered

196 30%

Recovered with lasting effects

26 3.9%

Still unwell when reported

278 42%

Died

38 5.8%

Euthanised

62 9.4%

Not known

60 9.1%

Problems reported at the same time

316 48%

194 29%

172 26%

150 23%

138 21%

115 17%

112 17%

99 15%

Age of the animals

Under 1 year

1–3 years

161

4–7 years

162

8–11 years

156

12+ years

128

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause disorientation in dogs?: 660 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Afoxolaner (NexGard) 663 reports · 1.2% of its reports
Disorientation after Sarolaner (Simparica) 349 reports · 2.1% of its reports
Disorientation after Lotilaner (Credelio) 109 reports · 1.1% of its reports
Disorientation after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 109 reports · 1.2% of its reports
Disorientation after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 28 reports · 0.9% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with disorientation