Elevated lipase after Lokivetmab (Cytopoint) in dogs

The FDA has received 39 reports of elevated lipase in dogs after Lokivetmab. That is 0.6% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

39Reports

64%Marked serious

10%Recovered

21%Died or euthanised

31 daysTypical onset

How soon it started

Same day

3 11%

1–2 days

2 7.4%

3–7 days

3 11%

1–4 weeks

4 15%

Over a month

15 56%

How the animals did

Recovered

4 10%

Still unwell when reported

20 51%

Died

3 7.7%

Euthanised

5 13%

Not known

7 18%

Problems reported at the same time

19 49%

17 44%

15 38%

12 31%

Didn't work as expected

11 28%

Elevated amylase

11 28%

Kidney problems

9 23%

Pancreatitis

9 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause elevated lipase in dogs?: 39 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

Elevated lipase after Bedinvetmab (Librela) 102 reports · 0.5% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with elevated lipase