Abdominal pain after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs

22 reports to the FDA describe abdominal pain in dogs given Ivermectin + Praziquantel + Pyrantel. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

22Reports

41%Marked serious

23%Recovered

27%Died or euthanised

–Typical onset

How the animals did

Recovered

4 18%

Recovered with lasting effects

1 4.5%

Still unwell when reported

3 14%

Died

3 14%

Euthanised

3 14%

Not known

8 36%

Problems reported at the same time

13 59%

9 41%

8 36%

7 32%

6 27%

5 23%

4 18%

3 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel + Pyrantel cause abdominal pain in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abdominal pain with similar medicines

Abdominal pain after Ivermectin + Pyrantel (Heartgard Plus) 222 reports · 0.2% of its reports
Abdominal pain after Milbemycin Oxime + Spinosad (Trifexis) 301 reports · 0.2% of its reports
Abdominal pain after Moxidectin (ProHeart 6) 193 reports · 0.4% of its reports
Abdominal pain after Milbemycin Oxime + Praziquantel (Interceptor Plus) 48 reports · 0.2% of its reports
Abdominal pain after Milbemycin Oxime (Interceptor) 96 reports · 0.3% of its reports
Abdominal pain after Selamectin (Revolution) 55 reports · 0.2% of its reports
Abdominal pain after Ivermectin (Heartgard) 47 reports · 0.4% of its reports

All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with abdominal pain