Abdominal pain after Moxidectin (ProHeart 6) in dogs

193 reports to the FDA describe abdominal pain in dogs given Moxidectin. That is 0.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

193Reports

33%Marked serious

8.3%Recovered

28%Died or euthanised

1 daysTypical onset

How soon it started

Same day

41 39%

1–2 days

27 26%

3–7 days

14 13%

1–4 weeks

6 5.8%

Over a month

16 15%

How the animals did

Recovered

16 8.3%

Still unwell when reported

69 36%

Died

42 22%

Euthanised

12 6.2%

Not known

54 28%

Problems reported at the same time

117 61%

113 59%

107 55%

72 37%

64 33%

56 29%

38 20%

34 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause abdominal pain in dogs?: 193 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abdominal pain with similar medicines

Abdominal pain after Ivermectin + Pyrantel (Heartgard Plus) 222 reports · 0.2% of its reports
Abdominal pain after Milbemycin Oxime + Spinosad (Trifexis) 301 reports · 0.2% of its reports
Abdominal pain after Milbemycin Oxime + Praziquantel (Interceptor Plus) 48 reports · 0.2% of its reports
Abdominal pain after Milbemycin Oxime (Interceptor) 96 reports · 0.3% of its reports
Abdominal pain after Selamectin (Revolution) 55 reports · 0.2% of its reports
Abdominal pain after Ivermectin (Heartgard) 47 reports · 0.4% of its reports
Abdominal pain after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 22 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with abdominal pain