Urinary incontinence after Imidacloprid + Moxidectin (Advantage Multi) in dogs

59 reports to the FDA describe urinary incontinence in dogs given Imidacloprid + Moxidectin. That is 0.4% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

59Reports

86%Marked serious

31%Recovered

17%Died or euthanised

2 daysTypical onset

How soon it started

Same day

9 23%

1–2 days

12 30%

3–7 days

5 13%

1–4 weeks

6 15%

Over a month

8 20%

How the animals did

Recovered

18 31%

Still unwell when reported

4 6.8%

Died

4 6.8%

Euthanised

6 10%

Not known

27 46%

Problems reported at the same time

16 27%

13 22%

13 22%

12 20%

11 19%

10 17%

9 15%

8 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause urinary incontinence in dogs?: 59 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

Urinary incontinence after Spinosad (Comfortis) 114 reports · 0.2% of its reports
Urinary incontinence after Lufenuron + Milbemycin Oxime (Sentinel) 63 reports · 0.2% of its reports
Urinary incontinence after Nitenpyram (Capstar) 34 reports · 0.3% of its reports
Urinary incontinence after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 21 reports · 0.2% of its reports
Urinary incontinence after Fipronil + S-methoprene (Frontline Plus) 23 reports · 0.8% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with urinary incontinence