Urinary incontinence after Spinosad (Comfortis) in dogs

114 reports to the FDA describe urinary incontinence in dogs given Spinosad. That is 0.2% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

114Reports

31%Marked serious

28%Recovered

8.8%Died or euthanised

2 daysTypical onset

How soon it started

Same day

16 35%

1–2 days

8 17%

3–7 days

1 2.2%

1–4 weeks

6 13%

Over a month

15 33%

How the animals did

Recovered

22 19%

Recovered with lasting effects

10 8.8%

Still unwell when reported

15 13%

Died

4 3.5%

Euthanised

6 5.3%

Not known

57 50%

Problems reported at the same time

34 30%

34 30%

17 15%

16 14%

14 12%

13 11%

11 9.6%

11 9.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause urinary incontinence in dogs?: 114 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

Urinary incontinence after Lufenuron + Milbemycin Oxime (Sentinel) 63 reports · 0.2% of its reports
Urinary incontinence after Imidacloprid + Moxidectin (Advantage Multi) 59 reports · 0.4% of its reports
Urinary incontinence after Nitenpyram (Capstar) 34 reports · 0.3% of its reports
Urinary incontinence after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 21 reports · 0.2% of its reports
Urinary incontinence after Fipronil + S-methoprene (Frontline Plus) 23 reports · 0.8% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with urinary incontinence