Unable to stand after Imidacloprid + Moxidectin (Advantage Multi) in dogs

39 reports to the FDA describe unable to stand in dogs given Imidacloprid + Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

39Reports
79%Marked serious
33%Recovered
26%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
15 43%
1–2 days
9 26%
3–7 days
4 11%
1–4 weeks
3 8.6%
Over a month
4 11%

How the animals did

Recovered
12 31%
Recovered with lasting effects
1 2.6%
Still unwell when reported
4 10%
Died
2 5.1%
Euthanised
8 21%
Not known
12 31%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
5
4–7 years
11
8–11 years
6
12+ years
12

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause unable to stand in dogs?
39 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unable to stand with similar medicines

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with unable to stand