Otitis externa after Imidacloprid + Moxidectin (Advantage Multi) in dogs
The FDA has received 24 reports of otitis externa in dogs after Imidacloprid + Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.
24Reports
79%Marked serious
46%Recovered
0.0%Died or euthanised
15 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Imidacloprid + Moxidectin cause otitis externa in dogs?
- 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 15 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Otitis externa with similar medicines
- Otitis externa after Spinosad (Comfortis) 61 reports · 0.1% of its reports
- Otitis externa after Lufenuron + Milbemycin Oxime (Sentinel) 31 reports · 0.1% of its reports
All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with otitis externa