Not drinking after Imidacloprid + Moxidectin (Advantage Multi) in dogs

29 reports to the FDA describe not drinking in dogs given Imidacloprid + Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

29Reports

45%Marked serious

38%Recovered

14%Died or euthanised

1 daysTypical onset

How soon it started

Same day

10 38%

1–2 days

10 38%

3–7 days

2 7.7%

1–4 weeks

3 12%

Over a month

1 3.8%

How the animals did

Recovered

11 38%

Still unwell when reported

6 21%

Died

2 6.9%

Euthanised

2 6.9%

Not known

8 28%

Problems reported at the same time

27 93%

16 55%

12 41%

7 24%

5 17%

Application site reaction

4 14%

Tremors

4 14%

Breathing problems

4 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause not drinking in dogs?: 29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

Not drinking after Spinosad (Comfortis) 241 reports · 0.4% of its reports
Not drinking after Lufenuron + Milbemycin Oxime (Sentinel) 61 reports · 0.2% of its reports
Not drinking after Nitenpyram (Capstar) 107 reports · 1.0% of its reports
Not drinking after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 30 reports · 0.3% of its reports
Not drinking after Fipronil + S-methoprene (Frontline Plus) 20 reports · 0.7% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with not drinking