Not drinking after Fipronil + S-methoprene (Frontline Plus) in dogs

20 reports to the FDA describe not drinking in dogs given Fipronil + S-methoprene. That is 0.7% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

20Reports
50%Marked serious
20%Recovered
5.0%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
2 13%
1–2 days
1 6.7%
3–7 days
5 33%
1–4 weeks
3 20%
Over a month
4 27%

How the animals did

Recovered
4 20%
Still unwell when reported
4 20%
Died
1 5.0%
Not known
11 55%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
3
4–7 years
8
8–11 years
4
12+ years
4

About this medicine

Fipronil kills fleas and ticks (spot-on).

Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Fipronil + S-methoprene cause not drinking in dogs?
20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with not drinking