Appetite loss after Fipronil + S-methoprene (Frontline Plus) in dogs
The FDA has received 41 reports of appetite loss in dogs after Fipronil + S-methoprene. That is 1.4% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.
41Reports
66%Marked serious
51%Recovered
4.9%Died or euthanised
35 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause appetite loss in dogs?
- 41 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 35 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Appetite loss with similar medicines
- Appetite loss after Spinosad (Comfortis) 91 reports · 0.2% of its reports
- Appetite loss after Lufenuron + Milbemycin Oxime (Sentinel) 34 reports · 0.1% of its reports
- Appetite loss after Imidacloprid + Moxidectin (Advantage Multi) 23 reports · 0.2% of its reports
- Appetite loss after Nitenpyram (Capstar) 32 reports · 0.3% of its reports
- Appetite loss after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 23 reports · 0.2% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with appetite loss