Appetite loss after Imidacloprid + Moxidectin (Advantage Multi) in dogs

The FDA has received 23 reports of appetite loss in dogs after Imidacloprid + Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

23Reports

70%Marked serious

48%Recovered

4.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

5 38%

1–2 days

4 31%

3–7 days

0 0.0%

1–4 weeks

3 23%

Over a month

1 7.7%

How the animals did

Recovered

11 48%

Still unwell when reported

6 26%

Died

1 4.3%

Not known

5 22%

Problems reported at the same time

14 61%

7 30%

6 26%

6 26%

Restlessness or agitation

5 22%

Skin redness

5 22%

Itching

4 17%

Liver problems

4 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause appetite loss in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Appetite loss with similar medicines

Appetite loss after Spinosad (Comfortis) 91 reports · 0.2% of its reports
Appetite loss after Lufenuron + Milbemycin Oxime (Sentinel) 34 reports · 0.1% of its reports
Appetite loss after Nitenpyram (Capstar) 32 reports · 0.3% of its reports
Appetite loss after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 23 reports · 0.2% of its reports
Appetite loss after Fipronil + S-methoprene (Frontline Plus) 41 reports · 1.4% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with appetite loss