Hind limb paresis after Imidacloprid + Moxidectin (Advantage Multi) in dogs
The FDA has received 21 reports of hind limb paresis in dogs after Imidacloprid + Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.
21Reports
48%Marked serious
9.5%Recovered
9.5%Died or euthanised
–Typical onset
Sponsored
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Imidacloprid + Moxidectin cause hind limb paresis in dogs?
- 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Hind limb paresis with similar medicines
- Hind limb paresis after Spinosad (Comfortis) 56 reports · 0.1% of its reports
- Hind limb paresis after Lufenuron + Milbemycin Oxime (Sentinel) 39 reports · 0.1% of its reports
All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with hind limb paresis