Swelling after Ilunocitinib (Zenrelia) in dogs

The FDA has received 81 reports of swelling in dogs after Ilunocitinib. That is 3.7% of all reports for this medicine, compared with 2.8% across reports for all dog medicines.

81Reports

47%Marked serious

17%Recovered

19%Died or euthanised

119 daysTypical onset

How soon it started

Same day

3 4.5%

1–2 days

6 9.1%

3–7 days

5 7.6%

1–4 weeks

7 11%

Over a month

45 68%

How the animals did

Recovered

14 17%

Still unwell when reported

30 37%

Died

2 2.5%

Euthanised

13 16%

Not known

22 27%

Problems reported at the same time

27 33%

21 26%

15 19%

15 19%

14 17%

14 17%

13 16%

12 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause swelling in dogs?: 81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 119 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Oclacitinib (Apoquel) 824 reports · 2.8% of its reports
Swelling after Cyclosporine (Atopica) 339 reports · 2.2% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with swelling