Urine abnormalities after Grapiprant (Galliprant) in dogs

54 reports to the FDA describe urine abnormalities in dogs given Grapiprant. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

54Reports
50%Marked serious
7.4%Recovered
13%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
3 6.7%
1–2 days
10 22%
3–7 days
3 6.7%
1–4 weeks
10 22%
Over a month
19 42%

How the animals did

Recovered
3 5.6%
Recovered with lasting effects
1 1.9%
Still unwell when reported
29 54%
Died
2 3.7%
Euthanised
5 9.3%
Not known
14 26%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
0
4–7 years
5
8–11 years
23
12+ years
20

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause urine abnormalities in dogs?
54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urine abnormalities with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with urine abnormalities