Neutropenia after Grapiprant (Galliprant) in dogs

30 reports to the FDA describe neutropenia in dogs given Grapiprant. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

30Reports
67%Marked serious
20%Recovered
17%Died or euthanised
47 daysTypical onset
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How soon it started

Same day
2 8.7%
1–2 days
2 8.7%
3–7 days
1 4.3%
1–4 weeks
5 22%
Over a month
13 57%

How the animals did

Recovered
6 20%
Still unwell when reported
9 30%
Died
1 3.3%
Euthanised
4 13%
Not known
10 33%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
1
4–7 years
1
8–11 years
14
12+ years
13

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause neutropenia in dogs?
30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 47 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutropenia with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with neutropenia