Neurological signs after Grapiprant (Galliprant) in dogs

The FDA has received 51 reports of neurological signs in dogs after Grapiprant. That is 0.6% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

51Reports
63%Marked serious
22%Recovered
25%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
13 28%
1–2 days
4 8.7%
3–7 days
5 11%
1–4 weeks
8 17%
Over a month
16 35%

How the animals did

Recovered
10 20%
Recovered with lasting effects
1 2.0%
Still unwell when reported
22 43%
Died
2 3.9%
Euthanised
11 22%
Not known
5 9.8%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
3
8–11 years
8
12+ years
39

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause neurological signs in dogs?
51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neurological signs with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with neurological signs