Hyperglycaemia after Grapiprant (Galliprant) in dogs

The FDA has received 56 reports of hyperglycaemia in dogs after Grapiprant. That is 0.6% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

56Reports
70%Marked serious
13%Recovered
25%Died or euthanised
35 daysTypical onset
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How soon it started

Same day
4 9.1%
1–2 days
5 11%
3–7 days
5 11%
1–4 weeks
8 18%
Over a month
22 50%

How the animals did

Recovered
7 13%
Still unwell when reported
22 39%
Died
2 3.6%
Euthanised
12 21%
Not known
13 23%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
4
8–11 years
27
12+ years
24

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause hyperglycaemia in dogs?
56 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperglycaemia with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with hyperglycaemia