Thrombocytosis after Fluralaner (Bravecto) in dogs

124 reports to the FDA describe thrombocytosis in dogs given Fluralaner. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

124Reports
91%Marked serious
8.1%Recovered
23%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
12 16%
1–2 days
12 16%
3–7 days
15 21%
1–4 weeks
13 18%
Over a month
21 29%

How the animals did

Recovered
3 2.4%
Recovered with lasting effects
7 5.6%
Still unwell when reported
63 51%
Died
7 5.6%
Euthanised
21 17%
Not known
23 19%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
6
4–7 years
35
8–11 years
38
12+ years
41

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause thrombocytosis in dogs?
124 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Thrombocytosis with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with thrombocytosis