Hypoglycaemia after Fluralaner (Bravecto) in dogs

The FDA has received 131 reports of hypoglycaemia in dogs after Fluralaner. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

131Reports
96%Marked serious
16%Recovered
40%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
18 20%
1–2 days
25 28%
3–7 days
12 14%
1–4 weeks
14 16%
Over a month
19 22%

How the animals did

Recovered
13 9.9%
Recovered with lasting effects
8 6.1%
Still unwell when reported
45 34%
Died
20 15%
Euthanised
33 25%
Not known
12 9.2%

Problems reported at the same time

Age of the animals

Under 1 year
10
1–3 years
27
4–7 years
36
8–11 years
37
12+ years
21

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause hypoglycaemia in dogs?
131 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoglycaemia with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with hypoglycaemia