High pancreatic-specific lipase after Fluralaner (Bravecto) in dogs

The FDA has received 77 reports of high pancreatic-specific lipase in dogs after Fluralaner. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

77Reports
92%Marked serious
9.1%Recovered
12%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
19 37%
1–2 days
9 17%
3–7 days
4 7.7%
1–4 weeks
2 3.8%
Over a month
18 35%

How the animals did

Recovered
6 7.8%
Recovered with lasting effects
1 1.3%
Still unwell when reported
48 62%
Died
1 1.3%
Euthanised
8 10%
Not known
13 17%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
10
4–7 years
22
8–11 years
22
12+ years
22

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause high pancreatic-specific lipase in dogs?
77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

High pancreatic-specific lipase with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with high pancreatic-specific lipase