Elevated lipase after Fluralaner (Bravecto) in dogs

216 reports to the FDA describe elevated lipase in dogs given Fluralaner. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

216Reports
97%Marked serious
13%Recovered
29%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
29 21%
1–2 days
34 24%
3–7 days
17 12%
1–4 weeks
19 14%
Over a month
40 29%

How the animals did

Recovered
22 10%
Recovered with lasting effects
6 2.8%
Still unwell when reported
85 39%
Died
19 8.8%
Euthanised
44 20%
Not known
40 19%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
42
4–7 years
47
8–11 years
74
12+ years
52

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause elevated lipase in dogs?
216 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with elevated lipase