Heart murmur after Fluralaner (Bravecto) in dogs

184 reports to the FDA describe heart murmur in dogs given Fluralaner. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

184Reports
95%Marked serious
31%Recovered
24%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
13 18%
1–2 days
14 19%
3–7 days
11 15%
1–4 weeks
10 14%
Over a month
25 34%

How the animals did

Recovered
4 2.2%
Recovered with lasting effects
53 29%
Still unwell when reported
73 40%
Died
16 8.7%
Euthanised
28 15%
Not known
10 5.4%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
23
4–7 years
39
8–11 years
58
12+ years
55

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause heart murmur in dogs?
184 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Heart murmur with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with heart murmur