Gall bladder & bile duct disorder after Fluralaner (Bravecto) in dogs

84 reports to the FDA describe gall bladder & bile duct disorder in dogs given Fluralaner. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

84Reports
99%Marked serious
9.5%Recovered
36%Died or euthanised
3 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
17 31%
1–2 days
10 18%
3–7 days
6 11%
1–4 weeks
8 15%
Over a month
14 25%

How the animals did

Recovered
6 7.1%
Recovered with lasting effects
2 2.4%
Still unwell when reported
36 43%
Died
13 15%
Euthanised
17 20%
Not known
10 12%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
7
4–7 years
24
8–11 years
32
12+ years
17

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause gall bladder & bile duct disorder in dogs?
84 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Gall bladder & bile duct disorder with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with gall bladder & bile duct disorder