Drooling after Fluralaner (Bravecto) in dogs

The FDA has received 769 reports of drooling in dogs after Fluralaner. That is 1.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

769Reports

82%Marked serious

35%Recovered

15%Died or euthanised

1 daysTypical onset

How soon it started

Same day

192 36%

1–2 days

121 23%

3–7 days

62 12%

1–4 weeks

47 8.9%

Over a month

105 20%

How the animals did

Recovered

253 33%

Recovered with lasting effects

13 1.7%

Still unwell when reported

300 39%

Died

50 6.5%

Euthanised

69 9.0%

Not known

84 11%

Problems reported at the same time

273 36%

242 31%

239 31%

199 26%

188 24%

129 17%

124 16%

117 15%

Age of the animals

Under 1 year

1–3 years

238

4–7 years

221

8–11 years

162

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause drooling in dogs?: 769 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Afoxolaner (NexGard) 913 reports · 1.6% of its reports
Drooling after Sarolaner (Simparica) 280 reports · 1.7% of its reports
Drooling after Lotilaner (Credelio) 134 reports · 1.3% of its reports
Drooling after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 130 reports · 1.4% of its reports
Drooling after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 44 reports · 1.4% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with drooling