Drooling after Lotilaner (Credelio) in dogs

The FDA has received 134 reports of drooling in dogs after Lotilaner. That is 1.3% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

134Reports
50%Marked serious
35%Recovered
13%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
34 30%
1–2 days
20 18%
3–7 days
8 7.1%
1–4 weeks
19 17%
Over a month
32 28%

How the animals did

Recovered
47 35%
Still unwell when reported
50 37%
Died
9 6.7%
Euthanised
9 6.7%
Not known
19 14%

Problems reported at the same time

Age of the animals

Under 1 year
38
1–3 years
38
4–7 years
31
8–11 years
17
12+ years
8

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause drooling in dogs?
134 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

All reported side effects of Lotilaner in dogs · Medicines most reported with drooling