Pain after Doxycycline in dogs

The FDA has received 130 reports of pain in dogs after Doxycycline. That is 3.2% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

130Reports

60%Marked serious

18%Recovered

22%Died or euthanised

26 daysTypical onset

How soon it started

Same day

23 23%

1–2 days

6 5.9%

3–7 days

9 8.8%

1–4 weeks

17 17%

Over a month

47 46%

How the animals did

Recovered

23 18%

Still unwell when reported

62 48%

Died

11 8.5%

Euthanised

17 13%

Not known

17 13%

Problems reported at the same time

56 43%

50 38%

35 27%

28 22%

27 21%

27 21%

25 19%

25 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause pain in dogs?: 130 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 26 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pain with similar medicines

Pain after Amoxicillin + Clavulanate (Clavamox) 130 reports · 2.4% of its reports
Pain after Cefovecin (Convenia) 108 reports · 2.9% of its reports
Pain after Enrofloxacin (Baytril) 99 reports · 2.6% of its reports
Pain after Metronidazole 70 reports · 2.3% of its reports
Pain after Amoxicillin 32 reports · 2.4% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with pain