Malaise after Doxycycline in dogs

35 reports to the FDA describe malaise in dogs given Doxycycline. That is 0.9% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

35Reports

63%Marked serious

17%Recovered

37%Died or euthanised

66 daysTypical onset

How soon it started

Same day

2 8.0%

1–2 days

2 8.0%

3–7 days

1 4.0%

1–4 weeks

4 16%

Over a month

16 64%

How the animals did

Recovered

6 17%

Still unwell when reported

11 31%

Died

6 17%

Euthanised

7 20%

Not known

5 14%

Problems reported at the same time

18 51%

15 43%

13 37%

13 37%

12 34%

9 26%

8 23%

8 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause malaise in dogs?: 35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 66 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Malaise with similar medicines

Malaise after Amoxicillin + Clavulanate (Clavamox) 49 reports · 0.9% of its reports
Malaise after Cefovecin (Convenia) 40 reports · 1.1% of its reports
Malaise after Enrofloxacin (Baytril) 36 reports · 1.0% of its reports
Malaise after Metronidazole 43 reports · 1.4% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with malaise