Elevated lipase after Doxycycline in dogs

The FDA has received 24 reports of elevated lipase in dogs after Doxycycline. That is 0.6% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

67%Marked serious

0.0%Recovered

46%Died or euthanised

26 daysTypical onset

How soon it started

Same day

2 10%

1–2 days

3 15%

3–7 days

2 10%

1–4 weeks

4 20%

Over a month

9 45%

How the animals did

Still unwell when reported

10 42%

Euthanised

11 46%

Not known

3 13%

Problems reported at the same time

20 83%

12 50%

12 50%

11 46%

11 46%

9 38%

Elevated cholesterol (total)

9 38%

Hyperphosphataemia

8 33%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause elevated lipase in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 26 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated lipase with similar medicines

Elevated lipase after Amoxicillin + Clavulanate (Clavamox) 40 reports · 0.7% of its reports
Elevated lipase after Cefovecin (Convenia) 38 reports · 1.0% of its reports
Elevated lipase after Enrofloxacin (Baytril) 38 reports · 1.0% of its reports
Elevated lipase after Metronidazole 46 reports · 1.5% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with elevated lipase