Elevated gamma-glutamyl transferase (ggt) after Doxycycline in dogs

57 reports to the FDA describe elevated gamma-glutamyl transferase (ggt) in dogs given Doxycycline. That is 1.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

57Reports
68%Marked serious
5.3%Recovered
32%Died or euthanised
24 daysTypical onset
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How soon it started

Same day
3 6.7%
1–2 days
3 6.7%
3–7 days
4 8.9%
1–4 weeks
15 33%
Over a month
20 44%

How the animals did

Recovered
3 5.3%
Still unwell when reported
22 39%
Died
3 5.3%
Euthanised
15 26%
Not known
14 25%

Problems reported at the same time

Liver problems
56 98%
Loss of appetite
27 47%
Vomiting
26 46%
Lethargy
22 39%
Death
19 33%
Leucocytosis
17 30%
Blood problems
15 26%
Kidney problems
14 25%

Age of the animals

Under 1 year
1
1–3 years
18
4–7 years
19
8–11 years
15
12+ years
4

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause elevated gamma-glutamyl transferase (ggt) in dogs?
57 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 24 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Doxycycline in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)