Collapse after Doxycycline in dogs

The FDA has received 89 reports of collapse in dogs after Doxycycline. That is 2.2% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported unusually often with this medicine.

89Reports

92%Marked serious

18%Recovered

35%Died or euthanised

31 daysTypical onset

How soon it started

Same day

10 14%

1–2 days

6 8.5%

3–7 days

7 9.9%

1–4 weeks

12 17%

Over a month

36 51%

How the animals did

Recovered

15 17%

Recovered with lasting effects

1 1.1%

Still unwell when reported

33 37%

Died

20 22%

Euthanised

11 12%

Not known

9 10%

Problems reported at the same time

36 40%

35 39%

32 36%

31 35%

30 34%

27 30%

24 27%

20 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause collapse in dogs?: 89 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

Collapse after Amoxicillin + Clavulanate (Clavamox) 104 reports · 1.9% of its reports
Collapse after Cefovecin (Convenia) 102 reports · 2.7% of its reports
Collapse after Enrofloxacin (Baytril) 77 reports · 2.0% of its reports
Collapse after Metronidazole 83 reports · 2.7% of its reports
Collapse after Amoxicillin 35 reports · 2.6% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with collapse