Proteinuria after Diphenhydramine in dogs

52 reports to the FDA describe proteinuria in dogs given Diphenhydramine. That is 1.1% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

52Reports
65%Marked serious
19%Recovered
19%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
11 24%
1–2 days
7 16%
3–7 days
6 13%
1–4 weeks
10 22%
Over a month
11 24%

How the animals did

Recovered
8 15%
Recovered with lasting effects
2 3.8%
Still unwell when reported
24 46%
Died
6 12%
Euthanised
4 7.7%
Not known
8 15%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
13
4–7 years
12
8–11 years
17
12+ years
8

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause proteinuria in dogs?
52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with proteinuria