Disorientation after Diphenhydramine in dogs

77 reports to the FDA describe disorientation in dogs given Diphenhydramine. That is 1.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

77Reports
53%Marked serious
29%Recovered
16%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
32 48%
1–2 days
11 16%
3–7 days
6 9.0%
1–4 weeks
5 7.5%
Over a month
13 19%

How the animals did

Recovered
18 23%
Recovered with lasting effects
4 5.2%
Still unwell when reported
28 36%
Died
7 9.1%
Euthanised
5 6.5%
Not known
15 19%

Problems reported at the same time

Age of the animals

Under 1 year
9
1–3 years
23
4–7 years
25
8–11 years
9
12+ years
11

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause disorientation in dogs?
77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with disorientation