Anxiety after Diphenhydramine in dogs

The FDA has received 74 reports of anxiety in dogs after Diphenhydramine. That is 1.6% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

74Reports
54%Marked serious
42%Recovered
4.1%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
26 45%
1–2 days
12 21%
3–7 days
4 6.9%
1–4 weeks
3 5.2%
Over a month
13 22%

How the animals did

Recovered
30 41%
Recovered with lasting effects
1 1.4%
Still unwell when reported
22 30%
Euthanised
3 4.1%
Not known
18 24%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
16
4–7 years
27
8–11 years
19
12+ years
10

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause anxiety in dogs?
74 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Anxiety with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with anxiety