Monocytosis after Dexmedetomidine (Dexdomitor) in dogs

49 reports to the FDA describe monocytosis in dogs given Dexmedetomidine. That is 0.9% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

49Reports

76%Marked serious

12%Recovered

37%Died or euthanised

8 daysTypical onset

How soon it started

Same day

5 12%

1–2 days

10 24%

3–7 days

6 14%

1–4 weeks

11 26%

Over a month

10 24%

How the animals did

Recovered

6 12%

Still unwell when reported

10 20%

Died

8 16%

Euthanised

10 20%

Not known

15 31%

Problems reported at the same time

34 69%

33 67%

29 59%

27 55%

24 49%

23 47%

21 43%

20 41%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Dexmedetomidine sedation and pain relief (also an oral gel for noise anxiety).

Products with this ingredient include Dexdomitor, Sileo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Dexmedetomidine cause monocytosis in dogs?: 49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Monocytosis with similar medicines

Monocytosis after Buprenorphine 65 reports · 4.1% of its reports

All reported side effects of Dexmedetomidine in dogs · Medicines most reported with monocytosis