Monocytosis after Buprenorphine in dogs

65 reports to the FDA describe monocytosis in dogs given Buprenorphine. That is 4.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

65Reports

91%Marked serious

6.2%Recovered

35%Died or euthanised

8 daysTypical onset

How soon it started

Same day

5 8.9%

1–2 days

15 27%

3–7 days

8 14%

1–4 weeks

15 27%

Over a month

13 23%

How the animals did

Recovered

4 6.2%

Still unwell when reported

22 34%

Died

8 12%

Euthanised

15 23%

Not known

16 25%

Problems reported at the same time

51 78%

43 66%

36 55%

32 49%

31 48%

27 42%

25 38%

23 35%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Buprenorphine pain relief (an opioid).

Questions owners ask

Can Buprenorphine cause monocytosis in dogs?: 65 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Monocytosis with similar medicines

Monocytosis after Dexmedetomidine (Dexdomitor) 49 reports · 0.9% of its reports

All reported side effects of Buprenorphine in dogs · Medicines most reported with monocytosis