Didn't work as expected after Dexmedetomidine (Dexdomitor) in dogs

The FDA has received 1,909 reports of didn't work as expected in dogs after Dexmedetomidine. That is 35% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,909Reports
32%Marked serious
42%Recovered
4.2%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
897 74%
1–2 days
78 6.5%
3–7 days
56 4.6%
1–4 weeks
99 8.2%
Over a month
76 6.3%

How the animals did

Recovered
789 41%
Recovered with lasting effects
5 0.3%
Still unwell when reported
265 14%
Died
45 2.4%
Euthanised
35 1.8%
Not known
770 40%

Problems reported at the same time

Age of the animals

Under 1 year
80
1–3 years
279
4–7 years
483
8–11 years
349
12+ years
81

About this medicine

Dexmedetomidine sedation and pain relief (also an oral gel for noise anxiety).

Products with this ingredient include Dexdomitor, Sileo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Dexmedetomidine cause didn't work as expected in dogs?
1,909 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

All reported side effects of Dexmedetomidine in dogs · Medicines most reported with didn't work as expected