Didn't work as expected after Buprenorphine in dogs

214 reports to the FDA describe didn't work as expected in dogs given Buprenorphine. That is 14% of all reports for this medicine, compared with 13% across reports for all dog medicines.

214Reports

64%Marked serious

36%Recovered

19%Died or euthanised

1 daysTypical onset

How soon it started

Same day

93 49%

1–2 days

25 13%

3–7 days

21 11%

1–4 weeks

19 9.9%

Over a month

33 17%

How the animals did

Recovered

75 35%

Recovered with lasting effects

1 0.5%

Still unwell when reported

41 19%

Died

16 7.5%

Euthanised

24 11%

Not known

57 27%

Problems reported at the same time

49 23%

43 20%

41 19%

40 19%

36 17%

Injection site reaction

36 17%

Swelling

35 16%

Liver problems

29 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Buprenorphine pain relief (an opioid).

Questions owners ask

Can Buprenorphine cause didn't work as expected in dogs?: 214 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

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All reported side effects of Buprenorphine in dogs · Medicines most reported with didn't work as expected