Swelling after Buprenorphine in dogs

236 reports to the FDA describe swelling in dogs given Buprenorphine. That is 15% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

236Reports

61%Marked serious

20%Recovered

22%Died or euthanised

1 daysTypical onset

How soon it started

Same day

98 46%

1–2 days

43 20%

3–7 days

26 12%

1–4 weeks

23 11%

Over a month

22 10%

How the animals did

Recovered

47 20%

Recovered with lasting effects

1 0.4%

Still unwell when reported

79 33%

Died

28 12%

Euthanised

23 9.7%

Not known

58 25%

Problems reported at the same time

Injection site reaction

90 38%

84 36%

63 27%

51 22%

46 19%

45 19%

43 18%

41 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Buprenorphine pain relief (an opioid).

Questions owners ask

Can Buprenorphine cause swelling in dogs?: 236 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

Swelling after Dexmedetomidine (Dexdomitor) 524 reports · 9.6% of its reports

All reported side effects of Buprenorphine in dogs · Medicines most reported with swelling